Biomechanics of suprachoroidal drug delivery: From benchtop to clinical investigation in ocular therapies

Introduction As research in suprachoroidal drug delivery advances, and therapeutic candidates, ranging from small molecule suspensions to gene therapy, progress through clinical trials, an understanding of space (SCS) biomechanics assumes increasing importance.Areas covered:Numerous anatomic features play important role access the SCS. Methods include a catheter, standard hypodermic needle, microinjector with microneedle. Physical fluidic properties injectates into SCS, such as volume, viscosity, particle size, osmotic pressure, ionic charge formulation can impact spread extent opening Pharmacokinetic data several yielded favorable ocular distribution pharmacokinetic profiles. Phase 2 3 trials have been completed suprachoroidally injected corticosteroid; results information on procedural details are discussed.Expert opinion Suprachoroidal has demonstrated be reliable consistent method for targeted treatment retinal choroidal disorders potentially maximize efficacy, while compartmentalizing therapies away unaffected tissues enhance safety. These attributes, along fluid transport formula customization pharmacological agents, may allow more tailored diseases affecting chorio-retinal tissues.